An exceptional opportunity to establish your flagship business in the heart of Downtown San Francisco, just minutes from Union Square. Situated between iconic Mason and Powell Street cable car lines, this side-by-side commercial duplex offers 2,192 square feet of inspiring, light-filled space with dramatic 16-foot ceilings, a central skylight and windows, and dual mezzanine office levels perfect for creative, retail, wellness, studio, or professional use. Originally built in 1921, the property blends historic character with meaningful upgrades, including copper water supply, upgraded electrical with smart meters, forced-air central heating, and separate water heaters. Each storefront is thoughtfully configured with its own kitchen and bathroom, providing flexibility for single or dual operations. The fully developed basement level adds significant functional space and upside potential, featuring ceiling heights approximating 7'6" at the rear and 7'3" toward the front, rear windows and exit doors, ideal for production, storage, rehearsal, or expanded business use. The 25' x 88' lot, RC-4 Zoned allowing for residential AND compatible commercial/retail uses, offers versatility for future expansion or re-imagining. Prior uses have included a hair salon and day spa, dance studio, bakery, and dry cleaning service, highlighting the property's adaptability. (Upstairs may allow for reapplication of a conditional-use hood and possible food permit.) Additional highlights include Recorded alley easement with gated access on Mason Street, a small rear yard area, including an hourly and monthly parking garage directly across the street. Prime location serving Union Square, Lower Nob Hill, and the Theatre District. Whether you envision a creative studio, wellness concept, boutique retail, professional offices, or a bold new flagship business, this property offers the space, character, and location to bring that vision to life. A rare owner-user opportunity in a re-emerging downtown corridor with enduring appeal and long-term potential.